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Interagency Assessment of Potential
Health Risks Associated with Oxygenated Gasoline
February 1996
National Science and Technology Council
Committee on Environment and
Natural Resources
Interagency Oxygenated Fuels Assessment Steering Committee
About the National Science and Technology Council
President Clinton established the National Science and Technology
Council (NSTC) by Executive Order on November 23, 1993. This
cabinet-level council is the principal means for the President to
coordinate science, space, and technology policies across the Federal
Government. NSTC acts as a "virtual" agency for science and technology
to coordinate the diverse parts of the Federal research and development
enterprise. The NSTC is chaired by the President. Membership consists
of the Vice President, Assistant to the President for Science and
Technology, Cabinet Secretaries and Agency Heads with significant
science and technology responsibilities, and other senior White House
officials.
An important objective of the NSTC is the establishment of clear
national goals for Federal science and technology investments in areas
ranging from information technologies and health research, to improving
transportation systems and strengthening fundamental research. The
Council prepares research and development strategies that are
coordinated across Federal agencies to form an investment package that
is aimed at accomplishing multiple national goals.
To obtain additional information regarding the NSTC, contact the NSTC
Executive Secretariat at 202-456-6100.
About the Office of Science and Technology Policy
The Office of Science and Technology Policy (OSTP) was established by
the National Science and Technology Policy, Organization, and Priorities
Act of 1976. OSTP's responsibilities include advising the President in
policy formulation and budget development on all questions in which
science and technology are important elements; articulating the
President's science and technology policies and programs, and fostering
strong partnerships among Federal, State, and local governments, and the
scientific commu nities in industry and academe.
To obtain additional information regarding the OSTP, contact the OSTP
Administrative Office at 202-395-7347.
Contents
Executive
Summary
Interagency
Oxygenated Fuels Assessment Steering Committee
Contributors
External
Reviewers
Acknowledgments
Chapter 1:
Introduction
Chapter 2:
Exposure/Dose Profile
Air Quality
Human Exposure Estimates for MTBE
Occupational Exposure - MTBE
Metabolism, Disposition, and Toxicokinetics of MTBE in Animals
Biological Measurements in Humans
Chapter 3: Acute
Health Effects
Epidemiologic Studies
Human Experimental Studies
Neurotoxic Potential of Methyl Teritary Butuyl Ether
Chapter 4:
Long-term or Chronic Effects
Genetic Toxicity Studies
Carcinogenicity Studies
Reproductive and Developmental Effects
Other Toxic Effects of Long-term Exposure to MTBE
Chapter 5: Risk
Characterization
Acute Health Effects
Cancer Risk Characterization
Chapter 6: Public
Health Research Needs
Appendix A: Summary of
Cancer Risk Derivations for MTBE
References
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