1. Support the development of a safe and effective HIV vaccine.
2. Support the development of new biochemical and genetic strategies to slow HIV disease progression
3. Support natural history studies for the purpose of evaluating the efficacy of intervention strategies.

1. Define the global molecular epidemiology of HIV to assist with candidate vaccine selection.
2. Explore novel vaccine technologies.
3. Conduct vaccine trials in endemic areas.
4. Assess the immune response and efficacy of vaccine candidates.
5. Evaluate potential therapies for treatment of HIV infection and potential for immune reconstitution.
6. Evaluate prevalence of drug resistance, develop rapid genetic assay for resistant mutants, and methods for genetic targeting of novel therapies in vivo.
7. Participate in national surveillance of AZT resistance.
8. Develop a comprehensive panel of immunologic, virologic, and functional parameters for management of HIV infection.
9. Support natural history studies and specimen repositories.

Vaccine, therapeutic, and epidemiological research, including vaccine design, development and testing in the U.S. and overseas locations; epidemiologic studies of vaccine field studies; and conclusion of drug treatment and behavior studies.

Active duty personnel.

Clinicians, researchers, and active duty personnel.