Goal #2 |
To conduct and support research to improve the understanding of HIV and the pathogenic mechanisms of HIV disease. |
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Objective #1 |
Delineate the cellular and molecular mechanisms associated with the viral immunopathogenesis of HIV-related immune dysfunction. |
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Action
Steps
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Descriptions
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Basic scientific information regarding the cellular and molecular mechanisms that underlie HIV-related immune dysfunction and viral pathogenesis is critical to all areas of AIDS research. |
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Objective #2 |
Delineate the molecular and cellular mechanisms of transmission and establishment of infection and their impact on disease progression. |
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Action
Steps
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Descriptions
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The mechanisms of HIV transmission and the early events in the establishment of infection, and their relationship to disease progression, need to be better understood. |
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Objective #3 |
Elucidate the etiologic factors and co-factors in the pathogenesis of AIDS-associated disease states. Enhance a bidirectional flow between basic and clinical observations and intervention programs ion HIV-related complications and foster interdisciplinary collaborations. |
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Description
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Knowledge of AIDS-associated disease pathogenesis is urgently needed. |
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Objective #3a |
Elucidate the etiologic factors, co-factors, and mechanisms in the pathogenesis of HIV-related malignancies. |
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Description
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Knowledge about the origins and pathogenesis of HIV-related cancers is urgently needed. |
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Action
Steps
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Objective #3b |
Elucidate the pathogenic mechanisms involved in HIV-associated neurological disease and neurobehavioral dysfunction. |
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Description
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The damage that leads to both central and peripheral nervous system dysfunction must be better understood through studies of HIV-associated neuropathogenesis. |
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Action
Steps
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Objective #3c |
Elucidate the pathogenic mechanisms of HIV-related opportunistic infections. |
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Description
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It is critical to understand the pathogenic mechanisms responsible for the development of HIV-associated OIs. |
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Action
Steps
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Objective #3c |
Elucidate the etiology and pathogenesis of HIV-related disorders: gastrointestinal, renal, endocrine, cardiovascular, cutaneous, hematologic, oral, pulmonary, and other diseases. |
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Description
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It is critical to understand various other organ/tissue-specific complications of HIV infection. |
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Action
Steps
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Resources
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FY95
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FY96
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FY96
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$
344.3 million
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$
382.9 million
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$
400.2 million
|
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Populations
Served |
All populations. |
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Constituency
Involvement |
Researchers, clinicians, community and patient representatives, and NIH-affiliated advisory councils and committees. |
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